Asymmetric Catalysis Special Feature Part I: Catalytic asymmetric addition of diphenylzinc to cyclic , -unsaturated ketones
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Catalytic asymmetric addition of diphenylzinc to cyclic , -unsaturated ketones
We have examined the use of our bis(sulfonamide) diol ligand (1) in the asymmetric addition of phenyl groups to cyclic , -unsaturated ketones. Good to excellent enantioselectivities have been obtained with cyclic enones bearing alkyl substituents in the 2 position (71–97% enantiomeric excess). Furthermore, excellent enantioselectivities have been observed in the asymmetric phenylation of cyclic...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2004
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0307119101